Synthesis and Antimicrobial Activity of Some Novel Benzo Thieno Pyrimidines
نویسندگان
چکیده
Cyclization and chlorination of 2-amino-5-benzyl-4, 5, 6, 7-tetrahydro hydro thieno [3, 2c] pyridine-3carboxamide yielded (3 a-b). Reaction with different substituted pyridines of [3 a-b] yielded 4a (1-4) and 4b (1-2). However reaction of 3a with different substituted 2-amino phenols yielded 4a (5-6). Further 3a yields 4a (7) & 4a (8) from different substituents like o-phenylene diamine and 4-chloro-2-triflouro acetyl aniline. Reaction of 3a & 3b with 2-amino Benzimidazole & 2-amino tetrazole yields 4a (9) & 4b (3), 4a (10) & 4b (4). All the synthesized compounds were tested against bacteria (Gram-positive and Gram–negative).
منابع مشابه
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